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How To Use Grapefruit Seed Extract (GSE) For Sinus Infections, Digestive Issues, UTI And Diabetes

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How To Use Grapefruit Seed Extract To Beat Sinus Infections

According to WebMD, 37 million Americans suffer from at least one episode of sinusitis each year. Sinus troubles leave many struggling for weeks and months on end. Stuffy and congested nose, pain between the eyes or in the forehead and upper teeth ache, are just some of the irritating and painful symptoms of a sinus infection. But there is a natural cure for sinus infection: grapefruit seed extract (GSE) is an extremely potent natural remedy that can effectively fight sinus infections.

From my own personal experience, I know that sinus infections can be truly debilitating and I’ve written a number of articles on how to beat sinus infection: the best home remedies for sinus infection and how to use horseradish to treat sinus infection. I believe that if you want to beat a sinus infection, it’s best to combine different types of treatments. In this article I want to describe how I virtually solved my chronic sinus infection using grapefruit seed extract (GSE).


Grapefruit seed extract (GSE), which is made from the pulp and the seeds of the grapefruit, acts as a natural antibiotic. It has antioxidant, antibacterial and antiviral properties and is a very versatile natural remedy.(1, 2, 3)

The grapefruit’s high vitamin C content and other healing nutrients help the body defeat infection and relieve congestion. GSE is considered to be an effective way to deal with sinusitis and has long lasting results.

I’ve used grapefruit seed extract when I had sinus infection that lasted a few weeks and I had great results. Within days I’ve noticed an amazing improvement: the pressure that I had in my sinuses has disappeared and I was able to breath properly through my nose. I found out that many other people had great experience when using GSE to treat their sinus infection.

What Can You Expect From GSE?

  • It’s antibacterial and antiviral but it doesn’t harm beneficial intestinal flora in the intestines.
  • It’s natural and safe and doesn’t contain any potentially harmful chemicals.
  • Unlike some other treatments, it doesn’t dry and dehydrate the body.
  • It stabilizes the body’s pH, which has an overall positive effect on the body and aids disease prevention.
  • It works as a natural antiseptic.
  • It’s easy to use.
  • It provides the body with some additional nutrients that support health and well-being.

How to Use Grapefruit Seed Extract to Treat Sinus Infections

You can take GSE in different forms: you can irrigate the nasal passages, take it in a capsule or tablet form or drink it mixed with water (or other fluid).

Based on my own experience, the most effective way to use GSE for sinus infection is to irrigate your sinuses using saline water mixed with a few drops of GSE. You should always mix the GSE with water as it’s extremely concentrated and it may burn and irritate your sinuses if it’s too concentrated.


It’s interesting to note that there is an approval of a patent discussing the use of grapefruit seed extract for cleansing the sinuses to reduce inflammation and improve breathing. There are other ingredients in the sinus irrigation liquid mentioned in the patent: baptisia tinctoria, colloidal silver, salt and water.(8)

How to Irrigate Your Sinuses With GSE

Mix a few drops of GSE with ¼ teaspoon of salt in a glass of warm water (240ml  / 8 fl oz). You should NEVER use tap water for your sinus irrigation – use bottled water that has been distilled or sterilized, or previously boiled and cooled down water to make sure it is free from bacteria.

Use the mixture to irrigate the nasal cavities – this is best done by using a sinus rinse bottle or a neti pot.

For those unfamiliar with a neti pot, this is a ceramic or plastic pot that has been used for centuries in Ayurvedic medicine. It acts as a container and is designed to rinse debris or mucus from your nasal cavity. The other option is to use a squeeze bottle (this is what I’ve used) and I found it very easy to use. You can find more information about the type of bottle I’ve used (including an image) in my article about the best home remedies for sinus infection.

When using GSE for the first time, start with only one drop to see how your body reacts to the GSE and this would also allow you to get used to the smell and taste of GSE as it’s quite bitter.


You can gradually increase the number of GSE drops you mix with your saline water. I’ve used 6 drops and I believe that this is the maximum that you should use. I’ve experimented with more than 6 drops but I found out that it started to irritate my sinuses.

I’ve washed my sinuses 3 times per day for a period of one week. It shouldn’t irritate your sinuses and it shouldn’t burn but it does have a certain bitter taste and smell. But don’t worry, you get used to the taste and smell quickly and after a few washes you won’t notice the taste or the smell.

Drink GSE Mixed With Water

Another option is to use GSE mixed with water (you can also use juice) – I’ve mixed 20 drops of GSE with half a glass of water and drank it 3 time a day. You should always start with just a few drops to see how your body reacts and then gradually increase the number of GSE drops you put in the water.

Your GSE may be more concentrated than mine so you may need to put a smaller number of drops and you should have the instructions on your GSE bottle.

Other Health Benefits of Grapefruit Seed Extract (GSE)

In addition to treating sinus infection, GSE was found to be helpful in treating digestive issue, diabetes and urinary tract infection (UTI).


Grapefruit Seed Extract for Treating Digestive Issues

Grapefruit seed extract can help treating H. pylori infection. (4) Helicobacter Pylori (H. pylori) is bacteria that may aggressively attack the lining of the stomach. Some of the symptoms of H. pylori infection are stomach ulcers, pain, and general digestive upset.  There are other proven natural remedies that can help treat Helicobacter Pylori infection.

Grapefruit seed extract can help to protect your stomach from damage caused by stress and alcohol consumption. (5)

A study found that grapefruit seed extract was effective in treating intestinal infections caused by Candida, Geotrichum sp and hemolytic E. Coli.  The participants in the study who received the GSE had a definite improvement in digestive issues such as constipation, flatulence, and abdominal discomfort. (6)

There are no exact guidelines on how much GSE you need to use in order to improve your digestive health. However in the last study I mentioned, participants consumed 2 drops of grapefruit seed extract mixed with 200 mL water twice daily for one month. (6)

Grapefruit Seed Extract Can Help Treat Urinary Tract Infection (UTI)

A small study from 2005 found that fresh or dried grapefruit seed extract can help treat UTI in men and women. (7)

The researchers suggest that “the 8-hourly dosage of 5 to 6 seeds of grapefruit seeds taken for a 2-week period may have an effect that is comparable to other proven antibacterial drugs.” (7)

However it is worth noting that it was a small study that only involved 4 patients.

Grapefruit Seed Extract Can Help Treating Type 1 and Type 2 Diabetes

A study on diabetic rats found that GSE can be helpful in reducing fasting blood glucose levels. The study also found that there was a reduction in the levels of LDL cholesterol (“bad” cholesterol) while the “good” HDL cholesterol increased.  The researchers concluded that “Results of this study lend support to the traditional use of grapefruit seeds in the management of type 1 diabetic patients” (8)

Another study concluded that GSE can be helpful in treating type 2 diabetes. The study found that GSE helped to reduce fasting blood glucose levels and reduce cardiovascular disease risks. (9)

Allergic Reactions To GSE

In rare cases, there have been reports of an allergy to GSE. The allergic reaction will usually present with rash, facial swelling, lightheadedness or a drop in blood pressure. If you experience such symptoms, you need to contact a doctor immediately.

Most people, however, report excellent results with no side effects, and the benefits of GSE can usually be observed very soon after taking the extract.

I am curious to know if you’ve used GSE in the past and what was your experience – please leave your message in the comments below.

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27 Responses to How To Use Grapefruit Seed Extract (GSE) For Sinus Infections, Digestive Issues, UTI And Diabetes

  1. Dawn says:

    I had an awful sinus infection and nothing seemed to work. I got NutriBiotic’s Nasal Spray Grapefruit Seed Extract. Took it three times a day and the very next day I started to feel better. It’s not too expensive and it’s very easy to use. My son also has problems with chronic sinus infections and I started him on a spray up each nose once a day and he hasn’t gotten an infection since he started.

    • Ann says:

      Hello, i am perusing through remedies for sinus infections and saw that you responded about a year ago. Was curious to know how the grapefruit seed nasal spray has been effective over the course of a year with you and your son. Seriously considering it. Thanks so much for your help.

  2. Melissa says:

    To drink it, you’re supposed to mix 10 drops with juice, 1 to 3 times a day (that’s what mine says to do) , but it doesn’t say, for how many days to do this… help?

  3. Karen says:

    I am a very long time sufferer of allergies that often manifest in sinus infections. I missed work and spent a great deal of money on OTC’s and or Rx’s from a physician. I currently am oxygen dependent because of COPD and sinus issues are segue for hospitalization for worse infections.

    About six months ago, I discovered Xylitol. Since then I have not been troubled with respiratory or sinus difficulties, and am not as stressed with COPD as well.

    I recommend you consider this as a suggestion in your letters.

    I use the nasal spray and the mints. I cannot use the gum, I have dentures. I would if I could and my grandson is chewing the gum now each day to prevent tooth decay.

    Xylitol is the best to come along for my family and I. Pass it on please?

  4. Ryan says:

    Xylitol nasal spray is the best of the best.

  5. Deb says:

    I have found that if you mix a few drops of GSE in black coffee, it counteracts the bitterness and isn’t quite so bad. I usually use a teeny dixie cup and mix the coffee a with 10-12 drops and down it and then chase it with regular coffee, or juice. I still have my sinus infection and I’m sure I need to be more persistent. Fairly certain it’s a fungus since antibiotics did’t do anything. Trying to stay off the surgeons table. Been there…done that with BOTH sides.

    • Michael says:

      You probably should irrigate your sinuses with gse and a bit of salt in a Neti Potti to get better results as it would get straight to the problem area . I had serious sinus issues which eventually resulted in perpetual bleeding . Not even normal salt an bicarbonate of soda in a netti potti helped . But 3 days after using gse , bleeding virtually all stopped and now I am on the recovery path .Still use gse twice daily to continue healing . Benefits are my sinuses are no longer swollen , blocked and I can breath again after months .. And I have stopped snoring .. my wife is delighted !

  6. Rachel says:

    I’ve been using nutribiotic gse nasal spray for a month and I’ve been able to stop using be conservation, which is great. One thing I’m getting though is as soon as I spray I sneeze anything from 15 mins to 1/2 hour sometimes. Would you know what causes it.

    • Jenny Hills says:

      Hi Rachel, I’ve seen other people complain about this issue in several forums, but I couldn’t find an answer from an authority source. I’m thinking maybe it’s allergic reaction to GSE but I cannot be really sure. You may wish to try using another nasal spray that doesn’t contain GSE and see if you have the same response or not.

  7. Kim says:

    I had a terrible sinus infection for a couple of months back in November. I have completly lost my sense of smell & taste. Took two rounds of antibiotics to feel better then doctor tried a third round to try to get my taste & smell back, which did not help. Has anyone experienced this?

    • PK says:

      Yes, I have. A roaring sinus infection!
      I had sinus surgery twice (ethmoidectomy) and I had used GSE for years to keep my sinuses clear of infection. Recently I had a very bad cold with a roaring sinus infection – Dr gave Rx Ceftin but there was still that horrible yellow discharge. So I used a couple of drops more of GSE than usual…(3 in all)
      BAD MISTAKE! I thought my sinuses were on fire. Re- rinsed with plain salt water (Dr. Neil) without much difference.
      Now several days later, infection gone – but so is my sense of small and taste. Will that come back?

      • Jenny says:

        Hi PK, I am sorry to hear about your sinus infection. GSE is extremely strong and potent and every person reacts differently to GSE – I was okay with 6 drops but everyone is different. This is why I mentioned that one needs to gradually add more drops to the water rinse bottle. You mentioned that you are okay now but did you try horseradish? you can read about it in my post on How To Use Horseradish For Sinus Infections also make sure to read my other post about sinus infection: The Best Home Remedies For Sinus Infection. It took me quite a while to recover from my sinus infection and even now my nose feels partially blocked. The doctors can’t really explain what’s the reason for that. I sure hope that you will get your sense of smell back but if you have any concerns it’s best to see your doctor. All the best!

  8. Valerie says:

    Thank you for your post. People, like myself, that take certain prescription medications cannot drink grapefruit juice. Would GSE have the same effect as the juice? I would love to be able to use it for my sinusitis.

    • Jenny says:

      Hi Valerie, I’ve seen that grapefruit seed extract can impair your body’s ability to absorb certain medications and can interfere with them. You should definitely consult with a doctor before taking it.

  9. Ray says:

    I am in the process of doing a parasite cleanse. I’m using gse as well as another product for this. I have used a netti pot in the past with good results. I have just tried adding one drop of gse to my new Navage nasal irrigator. I didn’t feel any adverse effects. Later, I will try two drops.

  10. Laura says:

    I used GSE in a netipot for a recurring sinus infection that I had previously taken steroids and antibiotics to get rid of….it came back a week after I finished the antibiotics so I went to the healthfood store and bought GSE extract to put in my neti pot. Results were amazing and it truly got rid of the infection. The infection was so bad I could smell it in my nasal passages, didn’t think anything was going to work. My dad caught also came down with the bug I had caught and the day that he did, I told him to go get GSE. His symptoms only lasted a day and never got to an infection. From now on, I will always know how to prevent this from happening again.

  11. Robin says:

    I am anti-biotic resistant. Have read numerous articles about one study using grapefruit seed extract for UTI’s, however, not one of these articles mentions how much to take in milligrams. All that is mentioned is to take 8 hourly doses of 5-6 seeds for 2 weeks. I need to convert this to milligrams. Help please and thanks.

    • Jenny Hills, Nutritionist and Medical Writer says:

      Hi Robin, when buying liquid GSE extract it is best to follow the manufacturer instructions on the product as the amount depends on the strength of the GSE. Since the supplements market is not regulated by the FDA, it’s hard to know the concentration of the product. According to WebMD website: “There is no firmly established dose of grape seed extract. Doses of between 100-300 milligrams/day have been used in studies and are prescribed in some European countries.”

  12. Tina says:

    I’ve been using YL essential grapefruit oil for 6 weeks in my water all day long. I had rotator cuff surgery and slacked on the water with the oil. Got a sinus infection! Started back with water and Grapefruit oil now for three days and am starting to feel much better. I also use YL R.C., Thieves, and Peppermint together and inhale it out if my hands after I rub it on my chest and temples. I also diffuse R.C. and peppermint!! Sleeping like a baby! Oils work and are awesome!!

  13. jo says:

    Hi …i had surgery two times for bad chronic sinusitis after all no cure observed and started bad post nasal drips ,all day and night i suffered and last i started to keep paper tissue in my pocket to spit due to frequent spitting ..taken antibiotics, vitamin c etc. and frequent visit to ENTs but not observed any cure…at last i find Grape seed extract capsule in net and started 100mg in morning and evening… observed great relief within few days…amazing result and now i am almost free from the postnasal dripping …i strongly suggesting to try this who are suffering from sinusitis post nasal dripping

  14. Jeanette says:

    I got rid of a horrible sinus infection 10 years ago with GSE . I had greenish puss coming out of my nose . I burned my nose because I used too much . However I didn’t have to get on antibiotics

  15. Amy says:

    Hi, so I don’t really get sinus infections, maybe ever, but I was searching online for some reminders on how to quickly unclog my nose with what I have here, eg. essential oils, neti pot, etc. when I saw this post.
    I haven’t had a bottle of GSE in a while, thanks for the reminder actually! From what I can tell, it seems like sinus infections are no joke, but neither is GSE so I can’t imagine a better fit. With my experience of using for myself, husband, and daughter over the years religiously any time we got sick, I would have to say that when it comes to infections in general my approach would be to go at it a little bit more intensely than anyone here has mentioned though. Again, I don’t know what sinus infections are like per se but I have this one clogged nostril and the pain it’s causing is ruining my day so if I had had GSE on hand you’d better bet that I’d be taking way more than a few drops. No time for that. Adding it to the neti pot though should be a big help in general, great idea.
    Here is how I’ve used it with phenomenal success (and everyone I’ve ever treated in my circle of friends and family). We took it internally. I would generally take 20-30 drops at a time, sometimes up to 3x a day. That’s if I was REALLY sick. But when that’s happened, it usually took 24-48 hour max, and it was almost a full recovery. Hand to God.
    For example, one time I was at the ER bc it was unfortunately just how it happened bc of the circumstances, but nonetheless I was there bc I had the worst sore throat I’d ever had in my life. I maybe had a low grade fever and nothing else, but I couldn’t open my mouth at all and I was in a lot of pain. They sent me home after a while with nothing- no information, no possible explanation, nothing. The doctor was a total prick, and when I asked ‘could it be strep?’ he was like “I guess I could do a scrape if you want,” but he didn’t think so and that there was a possibility that I was drug-seeking…. I was seriously so embarrassed. I left and cursed myself for even listening to my husband when he insisted I go see those a-holes, and started on my GSE immediately.
    I got a follow up call a few days later from the nurse asking how my strep throat was and did I take my antibiotics!!! If I wasn’t so proud of myself and my beloved GSE I’d have been furious. She was like, “Wait wait, what did you take? I need to try that let me write that down. Honey you had strep throat. That doesn’t go away so fast usually.”
    So whatever. All I know is that the next decade I had a few sore throats, GSE wiped it out in almost a day. Had a yearly cold or flu, same thing, a couple days tops. I used to get painful cold sores on the same spot on my lip a couple of times a year, I would take that and high dose with lysine and vitamin c powder, done in a few days. They would last weeks before I learned about GSE weeks people.
    I also starting using it on a semi regular basis as a cleansing/wellness supplement.

    ***You aren’t supposed to take it continuously. It’s best to give a break in the case of continual use, so I would usually do 6wk on, 2wk off or something close to that.***

    Here’s how I did it:
    • I took a glass jar (like an iced tea, Snapple bottle or something) and made a concoction for the day. I would make one full jar for each person if there was more than one person sick.
    • I filled it with orange juice (or any citrus juice will do, but that’s the key, citrus juice. Someone said coffee in these comments. Really? That’s really NOT what you want to do. If it’s mixed in citrus you cannot taste it. Not water, not coffee, mix it with oj and you’ll be good.)
    • I would draw lines on the bottle with sharpie dividing it in three, and I put about 50-60 drops of GSE into the bottle so that I would have three servings.
    •I would then either drink it as is or pour the one shots worth into a larger glass and fill it with more juice depending on how I felt. I just liked having them ready to go if I had to work or leave the house it was pretty made.
    • I personally always mix it in with a teaspoon of vitamin C powder as well, so it was really sour. But that’s about 5g maybe more so it was intense. I know that helped the process as well.
    I am going to go buy more now. I just haven’t needed it I’m so long I’ve kind of forgotten. I stopped getting cold sores. I haven’t had one in over 5,6 years *knock on wood* and I don’t know what made them retreat but I always felt like it was the GSE or oregano oil. They are both powerhouses of nature.
    Anyway hope that helps!!
    Best of luck to you all.

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